Skullgirls is, arguably, the first truely accessible mainstream fighting game. This is because the developer, Mike Z, has taken the time to implement accessibility, as explained here. This means that anyone, whether they have vision or not, can play on a relatively equal footing.
If you use NVDA, the process is, with patience and sometimes sighted help, relatively straightforward. However, there is one interesting conundrum that I came accross recently that I managed to solve in a fairly limited amount of time.The problem I found was that whilst the game worked perfectly well, I couldn't easily mute the speech from my screen reader, NVDA, without reaching over to my keyboard and pressing the control key. Whilst I don't mind doing it every once in a while, the training mode practically forces you to do it multiple times to stop the screen reader from speaking the previous combo's output. This is good say, if you've accidentally cancelled a combo too early and you want to just carry on your training session as quickly as possible.
Whilst playing in training mode, I realised a crucial factor that might just, with the right level of adjustment, allow the muting process to be mapped to an action on the controller: the fact that the right analogue stick is not used.
Admittedly, this doesn't account for controllers that don't have a second analogue stick, but it's probably safe to say that a lot of people playing skullgirls with a controller will be using one that has a pair of sticks. But How did we do it?
I knew from previously using Joy2Key for other games that theoretically my solution of mapping the control key to the right analogue stick was possible, but wasn't sure how to do it. After a while of digging through google, I couldn't find what I needed. Not content with giving up, I eventually stumbled across this instructibles.com page that explains how to do it, albeit for a different purpose.
I'll answer the second question first. The following steps will enable you, if you're playing with a screen reader, to mute it by pushing the right analogue stick in pretty much any direction. Below are the steps you should follow, and the tools you're going to need.